Whisk together all ingredients in a bowl with a spout.
1 3/4 cups ketchup, 1 cup bourbon, 1/4 cup apple cider vinegar, 1/3 cup packed brown sugar, 2 tablespoons Worcestershire sauce, 1 tablespoon liquid smoke, 1 tablespoon Dijon mustard, 3 tablespoons molasses, 2 tablespoons honey, 1 teaspoon garlic powder, 1 teaspoon onion powder, 2 teaspoons ancho chili powder, 2 teaspoons mesquite powder